Name: Sleep Inn Wytheville I-77 and I-81
Price range: $99 total
Rating: 9.2

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Your Southwestern Virginia Vacation

Embark on your next thrilling adventure with a Southwestern Virginia vacation package, and leave knowing the finer details are already organized. Plus with the ability to customize your getaway, it'll be one you won't forget. Your trip to Southwestern Virginia wouldn't be complete without getting to some of its most renowned cities, starting with Roanoke. A couple of the top attractions here include Berglund Center and Valley View Mall. Wytheville is another favorite with Southwestern Virginia travelers. Visitors to this destination enjoy Fort Chiswell Animal Park and Galewinds Amusement Park. From the instant you book your Southwestern Virginia vacation to the second you come back home, Expedia has you covered each step of the way.

The Latest Southwestern Virginia vacation packages

Price found within the past 48 hours. Click for updated prices.

Dailey Renewal Retreat Bed & Breakfast

Lindley Park

$421

per person

Jun 11 - Jun 14

found 14 hours ago

Roundtrip flight included

New York (NYC) to Greensboro (GSO)

9/10 Wonderful! (209 reviews)

This place will always be near and dear to my heart. The breakfast was absolutely delicious, the atmosphere was so cozy and loving I did not want to leave. It was a pleasure to meet Miss Jean Dailey and I hope to come back some time soon. Plus, the house is surrounded by some VERY delicious options for food. If you’re looking for a home-away-from-home getaway, that actually isn’t in the middle of nowhere, I highly recommend!

Reviewed on Aug 5, 2025

Hampton Inn Greensboro-Airport

$493

per person

Jun 11 - Jun 14

found 14 hours ago

Roundtrip flight included

New York (NYC) to Greensboro (GSO)

8.8/10 Excellent! (780 reviews)

Friendly staff. Good breakfast and coffee available all day and night.

Reviewed on Apr 2, 2026

Winston Sleeps 16 - 2 Kitchens Hot Tub

Save 100% on your flight

$1,510

per person

Jun 25 - Jun 30

found 18 hours ago

Roundtrip non-stop flight included

St. Louis (STL) to Greensboro (GSO)

No reviews

KingBed PetFriendly Washer Dryer Sleep16

Save 100% on your flight

$1,880

per person

Jun 25 - Jun 30

found 18 hours ago

Roundtrip non-stop flight included

St. Louis (STL) to Greensboro (GSO)

No reviews

Kernersville Hot Tub Pool Arcade Gym Wifi Coffee

Save 100% on your flight

$1,795

per person

Jun 25 - Jun 30

found 18 hours ago

Roundtrip non-stop flight included

St. Louis (STL) to Greensboro (GSO)

6/10 (4 reviews)

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Where to stay in Southwestern Virginia

Find the best Southwestern Virginia areas and neighborhoods for the activities you enjoy most. Learn more about Southwestern Virginia

Downtown Roanoke

While visiting Downtown Roanoke, you might make a stop by sights like Center in the Square and Virginia Museum of Transportation.

Discover the most popular places to visit in Southwestern Virginia

Virginia Tech University

4.5/5(586 reviews)

Enjoy the collegiate vibe around Virginia Tech University, a top college in Blacksburg. You can attend a sporting event while in the area.

Close up of Rocky Mountain Elk walking across gravel road

Virginia Safari Park

4.5/5(75 reviews)

See the exotic and native animals who live at Virginia Safari Park during your travels in Natural Bridge. While in this family-friendly area, you can savor the top-notch restaurants.

The Virginia Creeper Trail, the most popular bike route in the region. Abingdon, VA, USA

Virginia Creeper Trail Abingdon

4.5/5(66 reviews)

Explore the great outdoors at Virginia Creeper Trail Abingdon, a lovely green space in Abingdon. Make time to visit the area's shops, or simply enjoy its top-notch restaurants.

Southwestern Virginia Hotel Deals

The Inn at Virginia Tech and Skelton Conference Center

901 Prices Fork Road Blacksburg VA

Fully refundableReserve now, pay when you stay

$106 nightly

$111 total

May 10 - May 11

Total with taxes and fees

9.6/10 Exceptional! (1,046 reviews)

Very quiet upscale room

Reviewed on Apr 9, 2026

Country Inn & Suites by Radisson, Roanoke, VA

7860 Plantation Rd Roanoke VA

Fully refundable

$101 nightly

$114 total

May 3 - May 4

Total with taxes and fees

9.2/10 Wonderful! (2,168 reviews)

Staff was friendly & property was clean. Mexican restaurant next door was decent for dinner. Breakfast could be better.

Reviewed on Apr 10, 2026

Sleep Inn Wytheville I-77 and I-81

135 Nye Cir Wytheville VA

Fully refundable

$86 nightly

$99 total

Apr 19 - Apr 20

Total with taxes and fees

9.2/10 Wonderful! (1,929 reviews)

Breakfast was great and all items fresh. AC was excellent in our room. Our room was very clean .Staff was excellent too.

Reviewed on Apr 10, 2026

See all 1,748 properties in Southwestern Virginia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.